题目

个体最多有多少种HLA-DR基因?或者说,单个细胞表达多少种MHC II?
背景：来自wikipedia,In the Class-II locus,each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB3,-4 o -5).That means that one heterozygous individual can inherit 6 or 8 Class-II alleles,three or four from each progenitor.
问1：
wikipedia,In the Class-II locus,each person inherits one gene HLA-DRα (DRA1) and one or two genes HLA-DRβ (DRB1 and DRB4 o -5) or three genes (DRB1 and DRB2 and DRB3) .That means that one heterozygous individual can inherit 6 10 Class-II alleles,5 from each progenitor.
（当同源染色体分别是DR3,DR5,DR6其中之一时,MHC II 基因为10个）
问2：DR2 单体基因型含有B2 和B5基因,细胞会否经过重排最后只有B2 或者B5留在染色体上?另外,HLA的MHC II的3个基因座DP,DQ,DR会否重排最后只留下一个座的基因来翻译MHC II?
问3：
我认为这篇wiki 和这篇nature上用allele这个词没用对
wiki ：one heterozygous individual can inherit 6 or 8 Class-II alleles
nature：DRB1,DRB5 and DQ alleles on DR2 haplotype in Caucasians.
等位基因才是allele,但是DRB1,DRB5 and DQ根本不等位,因此,这两处的 alleles应该用genes来表达,

提问时间：2020-07-24

答案

HLA-DR 由一个alpha链,一个β链组成.Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done fo...